In late 2020, a Fantastic Four reboot in MCU was announced with Spider-Man: Homecoming trilogy director Jon Watts helming the production.
The arrival of the Fantastic Four in the MCU also poses new challenges regarding how they will be integrated into Phase 4 or 5's story.
The MCU could take inspiration from the Ultimate universe, as it did for many elements in Phase 1, to explain how the Fantastic Four got their powers.