The name of the game Sunday was defense and offensive rebounds for the Gamecocks, who controlled the game from the start with a 13-2 lead in just the first six minutes of the game.
The Huskies went on two runs -- a 9-0 run in the second quarter and a 10-0 one in the third -- but the Gamecocks kept the lead the entire game.
South Carolina guard Destanni Henderson and forward Aliyah Boston were the stars of Sunday's game. Henderson ended the game with 26 points and Boston with 11.
"I've been thinking about it since last season, everyone had a picture of me crying. But today we're national champions and I'm in tears," Boston said
"I know our players were exhausted, but they were determined to be champions today," said South Carolina coach Dawn Staley.
UConn was 11-0 in national championship games before Sunday, which all came under head coach Geno Auriemma.
Sunday's title game was a rematch. South Carolina beat UConn 73-57 in November in the Battle 4 Atlantis in the Bahamas, relying on 22 points from Boston
South Carolina has been the top-ranked team since the preseason and is 34-2 on the year, with each of its losses coming by 2 points or fewer.