Pep Guardiola's side and the Reds will meet each other in a match that could very well decide the destination of the league crown - and neither team will want to give an inch.
It may have taken a lot of effort in midweek to break down a stubborn Atletico Madrid, but City got their win in the end - and now turn their attention to an even tougher test.
Jurgen Klopp has a full squad to choose from too, according to the German, which will give him plenty of options as he attempts to swing the charge for the Premier League his way.