In the last 10 years, the Joker alone managed to claw his way to the center of attention in several movies, video games, and TV shows.
Gotham Knights' roster of villains looks as though it will leave the Clown Prince of Crime on the sidelines, but the confirmation of Mr. Freeze and Penguin
The same holds true for enemies such as Clayface, Mad Hatter, Professor Pyg, and the League of Assassins - the latter of whom were the equivalent of cannon fodder in Batman: Arkham City.