Barca entered the weekend in third but were jumped by Atletico Madrid on Saturday with the chance to return the favor with just a point in this one.
Sergino Dest has missed two games with his biceps injury, while also missing the United States men's national team's World Cup qualifying last month.
Against Barca, the defense must be quick to react to their dynamic passes or they risk their third league loss. Midfielders Fernando and Thomas Delaney remain out due to injury.