Barca entered the weekend in third but were jumped by Atletico Madrid on Saturday with the chance to return the favor with just a point in this one.
Second-place Sevilla are seven points clear of fifth place entering the day, while Barca are four clear, with both looking like near locks to qualify for next season's Champions League.
Sergino Dest has missed two games with his biceps injury, while also missing the United States men's national team's World Cup qualifying last month.
Striker Luke de Jong has tested positive for COVID-19 and remains out, but other than them, this is a full-strength Barca side expected to stay hot.
With Pierre-Emerick Aubameyang leading the way, Barca haven't lost in La Liga this calendar year, with the last defeat coming in December.
Against Barca, the defense must be quick to react to their dynamic passes or they risk their third league loss. Midfielders Fernando and Thomas Delaney remain out due to injury.